• Product NameETP46464
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.
• Target NameATM/ATR inhibitor; DNA-PK inhibitor; mTOR inhibitor; PI3K inhibitor
• CAS No. 1345675-02-6
• Calculated MW 470.52
• Formulation C30H22N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC(C)(C#N)C1=CC=C(C=C1)N1C(=O)OCC2=CN=C3C=CC(=CC3=C12)C1=CC2=CC=CC=C2N=C1
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:ATM; ATR; DNA-PK; mTOR; PI3Kα
  Boling pt:
  Melting pt:
  Solubility:DMSO: 6 mg/mL (12.75 mM)
  Appearance:Faint Red Solid Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Toledo LI, et al. Nat Struct Mol Biol, 2011, 18(6), 721-727.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting