• Product NameELN 441958
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityELN-441958 is a potent, neutral antagonist of B1 receptor, inhibits the binding of the B1 agonist ligand [3H]DAKD to IMR-90 cells with Ki of 0.26 nM. ELN-441958 is highly selective for B1 over B2 receptors, and >500/ 2000-fold selective for the B1 over _mu_/_delta_-opioid receptor.
• Target NameBradykinin Receptor antagonist
• CAS No. 913064-47-8
• Calculated MW 501.02
• Formulation C29H29ClN4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:ClC1=CC=CC2=C1C(=O)N(C2)C1=CC=CC(=C1)C(=O)N1CCC2(CC1)CCN(CC2)C1=CC=NC=C1
  Pathways:GPCR/G Protein
  Receptor:B1 Receptor
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hawkinson JE, et al. J Pharmacol Exp Ther.2007 Aug;322(2):619-630.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting