• Product NameAF 353
• Brief DescriptionInhibitors
• Purification95.00%
• Biological ActivityAF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).
• Target NameP2 Receptor antagonist
• CAS No. 865305-30-2
• Calculated MW 400.21
• Formulation C14H17IN4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(I)C=C(OC2=CN=C(N)N=C2N)C(=C1)C(C)C
  Pathways:Neuroscience
  Receptor:P2X3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gever JR, et al. Br J Pharmacol. 2010 Jul;160(6):1387-1398.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting