• Product NameCYT997 (Lexibulin)
• Brief DescriptionInhibitors
• Purification99.22%
• Biological ActivityLexibulin(CYT-997) is a potent tubulin polymerisation inhibitor? with IC50 of 10-100 nM in Y cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo.
• Target NameMicrotubule Associated inhibitor
• CAS No. 917111-44-5
• Calculated MW 434.53
• Formulation C24H30N6O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCC[C@@H](C1=CN=CC=C1)NC2=NC(=NC=C2C)C3=CC(=C(C=C3)NC(=O)NCC)OC
  Pathways:Cytoskeletal Signaling
  Receptor:microtubule
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 20 mg/mL (46.02 mM); DMSO: 86 mg/mL (197.91 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Burns CJ, et al. Mol Y Ther, 2009, 8(11), 3036-3045.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting