• Product NameDOV 21947 hydrochloride(Amitifadine hydrochloride)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAmitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). Ki values for SERT/NET/ DAT are 99/262/213 nM. The IC50 values for serotonin, norepinephrine and dopamine reuptake are 12/23/96 nM.
• Target Name5-HT Receptor inhibitor; Dopamine Receptor inhibitor; Norepinephrine inhibitor
• CAS No. 410074-74-7
• Calculated MW 264.58
• Formulation C11H12Cl3N
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:C1[C@H]2[C@@]1(CNC2)C3=CC(=C(C=C3)Cl)Cl.Cl
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:5-HT; Dopamine; Norepinephrine (NE)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Skolnick P, et al. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting