• Product NamePF 03716556
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.
• Target NameATPase inhibitor
• CAS No. 928774-43-0
• Calculated MW 394.48
• Formulation C22H26N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=C2[C@@H](CCOC2=CC=C1)NC3=CC(=CN4C3=NC(=C4)C)C(=O)N(C)CCO
  Pathways:Membrane transporter/Ion channel
  Receptor:H+/K+-ATPase
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 79 mg/mL (200.26 mM); DMSO: 79 mg/mL (200.26 mM)
  Appearance:Faint Yellow Solid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Mori, et al. J Pharmacol Exp Ther. 2009 Feb;328(2):671-9.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting