• Product NameDanusertib (PHA-739358)
• Brief DescriptionInhibitors
• Purification98.44%
• Biological ActivityDanusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2.
• Target NameAurora Kinase inhibitor; Bcr-Abl inhibitor; c-RET inhibitor; FGFR inhibitor; Trk receptor inhibitor
• CAS No. 827318-97-8
• Calculated MW 474.55
• Formulation C26H30N6O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)[C@@H](C5=CC=CC=C5)OC
  Pathways:Cell Cycle/Checkpoint; Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors; Chromatin/Epigenetic; Cytoskeletal Signaling
  Receptor:Aurora A; Aurora B; Aurora C; Abl; RET; FGFR1; TrkA
  Boling pt:
  Melting pt:
  Solubility:DMSO: 95 mg/mL (200.18 mM)
  Appearance:Faint Red Solid Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Carpinelli P, et al. Mol Y Ther, 2007, 12 Pt 1, 3158-3168.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting