• Product NameABT-737
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. Phase 2.
• Target NameBCL inhibitor; Bcr-Abl inhibitor
• CAS No. 852808-04-9
• Calculated MW 813.43
• Formulation C42H45ClN6O5S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN(C)CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]
  Pathways:Angiogenesis; Apoptosis; Cytoskeletal Signaling
  Receptor:Bfl-1; Bcl-2; Bcl-B; Bcl-w; Bcl-xL
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (122.93 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Konopleva M, et al. Y Cell, 2006, 10(5), 375-388.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting