- Product NameCX5461
- Brief DescriptionInhibitors
- Purification95.44%
- Biological ActivityCX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
- Target NameDNA/RNA Synthesis inhibitor
- CAS No. 1138549-36-6
- Calculated MW 513.61
- Formulation C27H27N7O2S
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;