• Product NameCX5461
• Brief DescriptionInhibitors
• Purification95.44%
• Biological ActivityCX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
• Target NameDNA/RNA Synthesis inhibitor
• CAS No. 1138549-36-6
• Calculated MW 513.61
• Formulation C27H27N7O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1CCCN(CC1)C1=NC2=C(C=C1)C(=O)C(C(=O)NCC1=NC=C(C)N=C1)=C1SC3=CC=CC=C3N21
  Pathways:DNA Damage/DNA Repair
  Receptor:Pol I-driven transcription of rRNA
  Boling pt:
  Melting pt:
  Solubility:DMF: 3 mg/mL warmed (5.84 mM)
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Drygin D, et al, Y Res, 2011, 71(4), 1418-1430.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting