• Product NameAGI-5198 (IDH-C35)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.
• Target NameDehydrogenase inhibitor
• CAS No. 1355326-35-0
• Calculated MW 462.57
• Formulation C27H31FN4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=NC=CN1CC(=O)N(C(C(=O)NC1CCCCC1)C1=CC=CC=C1C)C1=CC(F)=CC=C1
  Pathways:Metabolism
  Receptor:R132C-IDH1; R132H-IDH1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 14 mg/mL (30.26 mM); DMSO: 24 mg/mL (51.88 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rohle D, et al. Science, 2013, 340(6132), 626-630.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting