• Product NameNVP-ADW742
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityNVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
• Target NameIGF-1R inhibitor
• CAS No. 475489-15-7
• Calculated MW 453.38
• Formulation C28H31N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC1=NC=NC2=C1C(=CN2C1CC(CN2CCCC2)C1)C1=CC(OCC2=CC=CC=C2)=CC=C1
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:IGF-1R
  Boling pt:
  Melting pt:
  Solubility:DMSO: > 10mM
  Appearance:Yellow Solid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Mitsiades CS, et al. Y Cell, 2004, 5(3), 221-230.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting