• Product Name(+)-JQ-1
• Brief DescriptionInhibitors
• Purification99.91%
• Biological Activity(+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 1268524-70-4
• Calculated MW 456.99
• Formulation C23H25ClN4O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
  Pathways:Chromatin/Epigenetic
  Receptor:BRD4 (1); BRD4 (2)
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 91 mg/mL (199.12 mM); DMSO: 91 mg/mL warmed (199.12 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Filippakopoulos P, et al. Nature, 2010, 468(7327), 1067-1073.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting