• Product NamePHA-793887
• Brief DescriptionInhibitors
• Purification98.02%
• Biological ActivityPHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM. It is greater than 6-fold more selective for CDK2, 5, and 7 than CDK1, 4, and 9. Phase 1.
• Target NameCDK inhibitor
• CAS No. 718630-59-2
• Calculated MW 361.48
• Formulation C19H31N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)CC(=O)NC1=NNC2=C1CN(C(=O)C1CCN(C)CC1)C2(C)C
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK1/CyclinB; CDK2/CyclinA; CDK2/CyclinE; CDK5/p25; CDK7/CyclinH
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 72 mg/mL (199.18 mM); DMSO: 72 mg/mL (199.18 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Brasca MG, et al. Bioorg Med Chem, 2010, 18(5), 1844-1853.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting