• Product NameTacrolimus (FK506)
• Brief DescriptionInhibitors
• Purification99.94%
• Biological ActivityTacrolimus is a macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
• Target NamemTOR inhibitor
• CAS No. 104987-11-3
• Calculated MW 804.02
• Formulation C44H69NO12
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:FKBP-12
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 83 mg/mL (103.23 mM); DMSO: 94 mg/mL (116.91 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Flanagan WM, et al. Nature, 1991, 352(6338), 803-807.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting