• Product NameGuanfacine hydrochloride
• Brief DescriptionInhibitors
• Purification99.89%
• Biological ActivityGuanfacine HCl, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors.
• Target NameAdrenergic Receptor agonist
• CAS No. 29110-48-3
• Calculated MW 282.55
• Formulation C9H10Cl3N3O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:Cl.NC(N)=NC(=O)CC1=C(Cl)C=CC=C1Cl
  Pathways:GPCR/G Protein
  Receptor:α2A-adrenoceptor
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mM; Water 100 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pillidge K, et al. Br J Pharmacol. 2014 Oct; 171(20):4785-96.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting