• Product NameWP1066
• Brief DescriptionInhibitors
• Purification99.73%
• Biological ActivityWP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2 not JAK1 and JAK3. Phase 1.
• Target NameJAK inhibitor; STAT inhibitor
• CAS No. 857064-38-1
• Calculated MW 356.22
• Formulation C17H14BrN3O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
  Pathways:Angiogenesis; JAK/STAT signaling; Chromatin/Epigenetic; Stem Cells
  Receptor:JAK2; STAT3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 71 mg/mL (199.31 mM)
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Verstovsek S, et al. Clin Y Res, 2008, (3), 788-796.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting