• Product NameWiskostatin
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityWiskott-Aldrich syndrome protein (WASP) and WAVE stimulate actin-related protein (Arp)2/3-mediated actin polymerization, leading to diverse downstream effects, including the formation and remodeling of cell surface protrusions, modulation of cell migration, and intracytoplasmic propulsion of organelles and pathogens. Selective inhibitors of individual Arp2/3 activators would enable more exact dissection of WASP- and WAVE-dependent cellular pathways and are potential therapeutic targets for viral pathogenesis. Wiskostatin is a recently described chemical inhibitor that selectively inhibits neuronal WASP (N-WASP)-mediated actin polymerization in vitro.
• Target NameOthers inhibitor
• CAS No. 253449-04-6
• Calculated MW 426.15
• Formulation C17H18Br2N2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN(C)CC(O)CN1C2=C(C=C(Br)C=C2)C2=C1C=CC(Br)=C2
  Pathways:Others
  Receptor:WASP(Arp)2/3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Guerriero CJ, Weisz OA. Am J Physiol Cell Physiol. 2007 Apr;292(4):C1562-6.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting