- Product NameSKF-96365 hydrochloride
- Brief DescriptionInhibitors
- Purification99.48%
- Biological ActivitySKF-96365, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibited the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIγ or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 inhibited hERG current in a concentration-dependent manner.
- Target NameTRP/TRPV Channel inhibitor
- CAS No. 130495-35-1
- Calculated MW 402.91
- Formulation C22H27ClN2O3
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
