• Product NameEntacapone
• Brief DescriptionInhibitors
• Purification99.79%
• Biological ActivityEntacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa concentrations are reached as compared to the administration of levodopa and a decarboxylase inhibitor.
• Target NameTransferase inhibitor
• CAS No. 130929-57-6
• Calculated MW 305.29
• Formulation C14H15N3O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:CCN(CC)C(=O)/C(=C/C1=CC(=C(C(=C1)O)O)[N+](=O)[O-])/C#N
  Pathways:Metabolism
  Receptor:COMT
  Boling pt:
  Melting pt:162-163C
  Solubility:Ethanol: 2 mg/mL (6.55 mM); DMSO: 61 mg/mL (199.81 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. De Santi C, et al. Eur J Clin Pharmacol, 1998, 54(3), 215-219.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting