• Product Name2-Methoxyestradiol
• Brief DescriptionInhibitors
• Purification99.84%
• Biological Activity2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast Ys. Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis.
• Target NameHIF inhibitor; Microtubule Associated inhibitor
• CAS No. 362-07-2
• Calculated MW 302.41
• Formulation C19H26O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=C(C=C34)OC)O
  Pathways:Angiogenesis; Cytoskeletal Signaling; Chromatin/Epigenetic
  Receptor:HIF-1α; HIF-2α; Microtubule depolymerization
  Boling pt:464.4C
  Melting pt:188-190C
  Solubility:DMSO: 60 mg/mL (198.4 mM)
  Appearance:Gray Solid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rao PN, et al. Steroids. 2002, 67(13-14), 1079-1089.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting