• Product NameICG001
• Brief DescriptionInhibitors
• Purification99.95%
• Biological ActivityICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
• Target NameWnt/beta-catenin inhibitor
• CAS No. 847591-62-2
• Calculated MW 548.63
• Formulation C33H32N4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1CN([C@H]2CN(C(=O)[C@@H](N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6
  Pathways:Cytoskeletal Signaling; Stem Cells
  Receptor:Wnt/β-catenin
  Boling pt:
  Melting pt:
  Solubility:DMSO: 180 mM
  Appearance:White Crystal
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Emami KH, et al, Proc Natl Acad Sci USA, 2004, 101(34), 12682-12687.2. Teo JL, et al, Proc Natl Acad Sci USA, 2005, 102(34), 12171-12176.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting