• Product NameRaltegravir (MK-0518)
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityRaltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively.
• Target NameIntegrase inhibitor
• CAS No. 518048-05-0
• Calculated MW 444.42
• Formulation C20H21FN6O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)O)C(=O)NCC3=CC=C(C=C3)F
  Pathways:Microbiology&virology
  Receptor:Integrase (S217Q PFV); Integrase (WT PFV)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 88 mg/mL (198.01 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hare S, et al. Proc Natl Acad Sci U S A. 2010, 107(46), 20057-20062.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting