• Product NameGSK2578215A
• Brief DescriptionInhibitors
• Purification99.94%
• Biological ActivityGSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.
• Target NameLRRK2 inhibitor
• CAS No. 1285515-21-0
• Calculated MW 399.42
• Formulation C24H18FN3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:O=C(C1=C(OCC2=CC=CC=C2)C=CC(C3=CC(F)=NC=C3)=C1)NC4=CC=CN=C4
  Pathways:Autophagy
  Receptor:LRRK2 (G2019S); LRRK2 (WT)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 79 mg/mL warmed (197.78 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Reith AD, et al. Bioorg Med Chem Lett. 2012, 22(17), 5625-5629.2. Saez-Atienzar S, et al. Cell Death Dis. 2014, 5, e1368.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting