• Product NameJNJ-26854165 (Serdemetan)
• Brief DescriptionInhibitors
• Purification99.48%
• Biological ActivitySerdemetan(JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.
• Target NameMdm2 inhibitor; p53 activator
• CAS No. 881202-45-5
• Calculated MW 328.42
• Formulation C21H20N4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C(CC1=CNC2=CC=CC=C12)NC1=CC=C(NC2=CC=NC=C2)C=C1
  Pathways:Apoptosis
  Receptor:HDM2; Mdm2; p53
  Boling pt:615.103C
  Melting pt:
  Solubility:Ethanol: 2 mg/mL (6.08 mM); DMSO: 66 mg/mL (200.96 mM)
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kojima K, et al. Mol Y Ther. 2010, 9(9), 2545-2557.2. Yuan Y, et al. J Hematol Oncol. 2011, 4:16.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting