• Product NameESI-09
• Brief DescriptionInhibitors
• Purification99.57%
• Biological ActivityESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.
• Target NamecAMP inhibitor
• CAS No. 263707-16-0
• Calculated MW 330.77
• Formulation C16H15ClN4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC(C)(C)C1=CC(=NO1)C(=O)/C(=N/NC2=CC(=CC=C2)Cl)/C#N
  Pathways:GPCR/G Protein
  Receptor:EPAC1; EPAC2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 20 mg/mL warmed (60.46 mM); DMSO: 66 mg/mL (199.53 mM)
  Appearance:Orange Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Almahariq M , et al. Mol Pharmacol. 2013, 83(1), 122-128.2. Gong B, et al. Proc Natl Acad Sci U S A. 2013, 110(48), 19615-19620.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting