• Product NameCL-387785 (EKI-785)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level.
• Target NameEGFR inhibitor
• CAS No. 194423-06-8
• Calculated MW 381.23
• Formulation C18H13BrN4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC#CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC1=CC(Br)=CC=C1
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 63 mg/mL warmed (165.25 mM)
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Discafani CM, et al. Biochem Pharmacol. 1999 Apr 15;57(8):917-25.2. Sweeney WE, et al. Kidney Int. 2000 Jan;57(1):33-40.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting