• Product NameLRRK2-IN-1
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.
• Target NameCDK inhibitor; LRRK2 inhibitor
• CAS No. 1234480-84-2
• Calculated MW 571
• Formulation C31H38N8O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=C(NC2=NC=C3N(C)C(=O)C4=CC=CC=C4N(C)C3=N2)C=CC(=C1)C(=O)N1CCC(CC1)N1CCN(C)CC1
  Pathways:Autophagy; Cell Cycle/Checkpoint
  Receptor:DCLK1; DCLK2; LRRK2 (A2016T); LRRK2 (G2019S); LRRK2 (WT)
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 100 mg/mL (175.22 mM); DMSO: 100 mg/mL (175.22 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Deng X, et al. Nat Chem Biol. 2011, 7(4), 203-205.2. Yao C, et al. Hum Mol Genet. 2013, 22(2), 328-344.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting