• Product NameKenPaullone
• Brief DescriptionInhibitors
• Purification98.99%
• Biological ActivityKenpaullone, a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp3 gene by enhancing TGFβ-Smad3 signaling pathway.
• Target NameCDK inhibitor; GSK-3 inhibitor
• CAS No. 142273-20-9
• Calculated MW 327.18
• Formulation C16H11BrN2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:BrC1=CC2=C(NC3=C2CC(=O)NC2=CC=CC=C32)C=C1
  Pathways:PI3K/Akt/mTOR signaling; Cell Cycle/Checkpoint; Stem Cells
  Receptor:CDK1/CyclinB; CDK2/CyclinA; CDK2/CyclinE; CDK5/p35; GSK-3β
  Boling pt:613C
  Melting pt:>300C
  Solubility:DMSO: > 10 mM
  Appearance:Yellowish-brown Solid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gu H, et al. Cell Immunol. 2014 Jul;290(1) :138-44. 2. Yoshida H, et al. Biochem Biophys Res Commun. 2013 Jun 7;435(3):378-84.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting