• Product NameAS-605240
• Brief DescriptionInhibitors
• Purification99.91%
• Biological ActivityAS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC50 = 8 nM). AS-605240 displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα.
• Target NamePI3K inhibitor
• CAS No. 648450-29-7
• Calculated MW 257.27
• Formulation C12H7N3O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1=CC2=NC=CN=C2C=C1/C=C/3\C(=O)NC(=O)S3
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 0.4 mg/mL (1.55 mM)
  Appearance:Orange Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Camps M, et al. Nat Med, 2005, 11(9), 936-943.2. Kim JI, et al. Nat Neurosci, 2011, 14(11), 1447-1454.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting