• Product NameXEN-445
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityXEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.
• Target NameLipase inhibitor
• CAS No. 1515856-92-4
• Calculated MW 366.33
• Formulation C18H17F3N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1CN(C[C@H]1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O
  Pathways:Metabolism
  Receptor:endothelial lipase
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 34 mg/mL warmed (92.81 mM); DMSO: 80 mg/mL (218.38 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sun S, et al. Bioorg Med Chem. 2013, 21(24), 7724-7734.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting