• Product NameTAE684 (NVP-TAE684)
• Brief DescriptionInhibitors
• Purification99.82%
• Biological ActivityTAE684 (NVP-TAE684) is a potent and selective ALK inhibitor with IC50 of 3 nM in a cell-free assay, 100-fold more sensitive for ALK than InsR.
• Target NameALK inhibitor
• CAS No. 761439-42-3
• Calculated MW 614.2
• Formulation C30H40ClN7O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)COC3=CC=CC=C3)C(=O)O)C
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK
  Boling pt:791C
  Melting pt:
  Solubility:DMSO: 3 mg/mL (4.88 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Galkin AV, et al. Proc Natl Acad Sci U S A, 2007, 104(1), 270-275.2. Katayama R, et al. Proc Natl Acad Sci U S A, 2011, 108(18), 7535-7540.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting