• Product NameTCS PIM-1 1
• Brief DescriptionInhibitors
• Purification99.64%
• Biological ActivityTCS PIM-1 1(sc-204330) is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).
• Target NamePim inhibitor
• CAS No. 491871-58-0
• Calculated MW 367.2
• Formulation C18H11BrN2O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:OC1=C(C=C(Br)C=C1)C1=CC(C2=CC=CC=C2)=C(C#N)C(=O)N1
  Pathways:Chromatin/Epigenetic; JAK/STAT signaling
  Receptor:Pim1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mM
  Appearance:Faint Yellow Crystalline Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Cheney IW, et al. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1679-83.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting