• Product NameSB743921
• Brief DescriptionInhibitors
• Purification95.58%
• Biological ActivitySB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. Phase 1/2.
• Target NameKSP inhibitor
• CAS No. 940929-33-9
• Calculated MW 553.52
• Formulation C31H34Cl2N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC=C(C=C1)C(=O)N(CCCN)[C@@H](C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl
  Pathways:Cell Cycle/Checkpoint
  Receptor:KSP; KSP (Colo205 cells); KSP (MV522 cells); KSP (MX1 cells); KSP (SKOV3 cells)
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 111 mg/mL (200.53 mM); Water: 22 mg/mL (39.74 mM); DMSO: 111 mg/mL (200.53 mM)
  Appearance:White Crystalline Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Jackson JR, et al. AACR, 2006, Abst 0906.2. Sakowicz R, et al. Y Res, 2004, 64(9), 3276-3280.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting