• Product NameCNX-1351
• Brief DescriptionInhibitors
• Purification99.69%
• Biological ActivityCNX-1351 is a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kα with IC50 of 6.8 nM; 20-400 times less potent against β, γ, and δ.
• Target NamePI3K inhibitor
• CAS No. 1276105-89-5
• Calculated MW 573.71
• Formulation C30H35N7O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C/C(C)=C\C(CCC(N1CCN(CC(S2)=CC3=C2C(N4CCOCC4)=NC(C5=C6C=NNC6=CC=C5)=N3)CC1)=O)=O
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI3Kα
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Crystalline Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Nacht M, et al. J Med Chem. 2013 Feb 14;56(3):712-21.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting