• Product NameCX-4945 (Silmitasertib)
• Brief DescriptionInhibitors
• Purification98.04%
• Biological ActivityCX-4945 (Silmitasertib) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Phase 1/2.
• Target NameCasein Kinase inhibitor
• CAS No. 1009820-21-6
• Calculated MW 349.77
• Formulation C19H12ClN3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:OC(=O)C1=CC2=NC(NC3=CC(Cl)=CC=C3)=C3C=CN=CC3=C2C=C1
  Pathways:Metabolism; Stem Cells
  Receptor:CK2
  Boling pt:568.45C
  Melting pt:
  Solubility:DMSO: 16 mg/mL (45.74 mM)
  Appearance:Yellowish-brown Solid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Siddiqui-Jain A, et al. Y Res, 2010, 70(24), 10288-10298.2. Pierre F, et al. J Med Chem, 2011, 54(2), 635-654.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting