• Product NameGW 9662
• Brief DescriptionInhibitors
• Purification99.74%
• Biological ActivityGW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM in a cell-free assay, with at least 100 to 1000-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ.
• Target NamePPAR antagonist
• CAS No. 22978-25-2
• Calculated MW 276.68
• Formulation C13H9ClN2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:[O-][N+](=O)C1=CC(C(=O)NC2=CC=CC=C2)=C(Cl)C=C1
  Pathways:Metabolism
  Receptor:PPARα; PPARγ; PPARδ
  Boling pt:360.9C
  Melting pt:171-175C
  Solubility:DMSO: 55 mg/mL (198.78 mM)
  Appearance:Faint Yellow Crystalline Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Collino M, et al. Kidney Int, 2005, 68(2), 529-536.2. Seargent JM, et al. Br J Pharmacol, 2004, 143(8), 933-937.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting