• Product NameIM-12
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityIM-12 is a potent GSK-3β inhibitor with IC50 of 53 nM; shows a significant activity in several biological tests which was comparable or even outplayed the effects of the known SB-216763.
• Target NameGSK-3 inhibitor
• CAS No. 1129669-05-1
• Calculated MW 377.41
• Formulation C22H20FN3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN1C(=O)C(NCCC2=CC=C(F)C=C2)=C(C1=O)C1=C(C)NC2=CC=CC=C12
  Pathways:PI3K/Akt/mTOR signaling; Stem Cells
  Receptor:GSK-3β
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 10 mg/mL warmed (26.49 mM); DMSO: 75 mg/mL (198.72 mM)
  Appearance:Orange Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Schmole AC, et al. Bioorg Med Chem. 2010 Sep 15;18(18):6785-95.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting