• Product NameCHF5074
• Brief DescriptionInhibitors
• Purification99.79%
• Biological ActivityCHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.
• Target NameBeta Amyloid inhibitor; Gamma-secretase modulator
• CAS No. 749269-83-8
• Calculated MW 325.16
• Formulation C16H11Cl2FO2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:OC(=O)C1(CC1)C1=CC(F)=C(C=C1)C1=CC(Cl)=C(Cl)C=C1
  Pathways:Neuroscience; Proteases/Proteasome; Stem Cells
  Receptor:Beta Amyloid; γ secretase
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Imbimbo BP, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. 2. Ronsisvalle N, et al. Curr Alzheimer Res. 2014;11(7):714-24.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting