• Product NameVX661
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityVX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.
• Target NameCFTR modulator
• CAS No. 1152311-62-0
• Calculated MW 520.5
• Formulation C26H27F3N2O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)(CO)C1=CC2=CC(=C(C=C2N1C[C@H](CO)O)F)NC(=O)C3(CC3)C4=CC5=C(C=C4)OC(O5)(F)F
  Pathways:Membrane transporter/Ion channel
  Receptor:VFTR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (192.12 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pettit RS, Fellner C. P T. 2014 Jul;39(7):500-11.2. Veit G, et al. Sci Transl Med. 2014 Jul 23;6(246):246ra97.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting