• Product NameSBE 13 hydrochloride
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySBE13 hydrochloride is a potent and selective PLK1 with IC50 of 0.2 nM; no inhibition om Aurora A kinase, Plk2 and Plk3.
• Target NamePLK inhibitor
• CAS No. 1052532-15-6
• Calculated MW 479.4
• Formulation C24H28Cl2N2O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:Cl.COC1=C(OC)C=C(CCNCC2=CC(OC)=C(OCC3=CN=C(Cl)C=C3)C=C2)C=C1
  Pathways:Cell Cycle/Checkpoint
  Receptor:PLK1; PLK2; PLK3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 95 mg/mL (198.16 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Keppner S, et al. ChemMedChem. 2009 Nov;4(11):1806-9.2. Lange L, et al. Oncotarget. 2014 Apr 30;5(8):2263-75.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting