• Product NameYK-4-279
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityYK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. YK-4-279 inhibits Ewing's sarcoma family tumor (ESFT) cell growth; YK-4-279 induces apoptosis.
• Target NameDNA/RNA Synthesis inhibitor
• CAS No. 1037184-44-3
• Calculated MW 366.2
• Formulation C17H13Cl2NO4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC=C(C=C1)C(=O)CC1(O)C(=O)NC2=C(Cl)C=CC(Cl)=C12
  Pathways:DNA Damage/DNA Repair
  Receptor:RNA helicase A
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 51 mg/mL warmed (139.26 mM); DMSO: 73 mg/mL (199.34 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Erkizan HV, et al. Nat Med. 2009, 15(7), 750-756.2. Rahim S, et al. PLoS One. 2011, 6(4), e19343.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting