• Product NameLosmapimod (GW856553X)
• Brief DescriptionInhibitors
• Purification98.88%
• Biological ActivityLosmapimod (GW856553X; SB856553; GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.
• Target Namep38 MAPK inhibitor
• CAS No. 585543-15-3
• Calculated MW 383.46
• Formulation C22H26FN3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(F)C=C(C=C1C1=NC=C(C=C1)C(=O)NCC(C)(C)C)C(=O)NC1CC1
  Pathways:MAPK
  Receptor:p38α; p38β
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 41 mg/mL warmed (106.92 mM); DMSO: 76 mg/mL (198.19 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Willette RN, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):964-70.2. Ostenfeld T, et al. Eur J Pain. 2013 Jul;17(6):844-57.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting