• Product NamePX-12
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1(Trx-1) currently in clinical development as an antitumor agent; IC50=7 uM in Hela, MTT assay, 72 h.
• Target NameThioredoxin inhibitor
• CAS No. 141400-58-0
• Calculated MW 188.32
• Formulation C7H12N2S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC(CC)SSC1=NC=CN1
  Pathways:Metabolism
  Receptor:TRX (HT-29 cells); TRX (MCF-7)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mM
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Shin HR, et al. Oncol Lett. 2013 Dec;6(6):1804-1810.2. Baker AF, et al.J Lab Clin Med. 2006 Feb;147(2):83-90.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting