• Product NameEVP-6124 hydrochloride
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityEVP-6124 hydrochloride is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). EVP-6124 showed selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs.
• Target NameAChR antagonist
• CAS No. 550999-74-1
• Calculated MW 357.3
• Formulation C16H17ClN2OSHCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:C1CN2CCC1[C@H](C2)NC(=O)C3=CC4=C(S3)C(=CC=C4)Cl.Cl
  Pathways:Neuroscience
  Receptor:α7 nAChR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL
  Appearance:Yellowish-brown Crystal
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Prickaerts J, et al. Neuropharmacology. 2012 Feb;62(2):1099-110.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting