• Product NamePIK-75
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPIK-75 is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM.
• Target NameDNA-PK inhibitor; PI3K inhibitor
• CAS No. 372196-77-5
• Calculated MW 488.74
• Formulation C16H14BrN5O4SHCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.Cl
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:DNA-PK; p110α; p110β; p110γ; p110δ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 3 mg/mL (6.13 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zheng Z, et al. Mol Pharmacol. 2011, 80(4), 657-664.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting