• Product NameMotesanib (AMG-706)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityMotesanib is an orally bioavailable receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), Kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.
• Target NameVEGFR inhibitor
• CAS No. 453562-69-1
• Calculated MW 373.46
• Formulation C22H23N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1(C)CNC2=C1C=CC(NC(=O)C1=C(NCC3=CC=NC=C3)N=CC=C1)=C2
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:VEGFR1; VEGFR2; VEGFR3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Polverino A, et al.Y Res, 2006, 66(17), 8715-8721.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting