• Product NameMotesanib Diphosphate (AMG-706)
• Brief DescriptionInhibitors
• Purification99.33%
• Biological ActivityMotesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit, ~10-fold more selective for VEGFR than PDGFR and Ret. Phase 3.
• Target Namec-Kit inhibitor; VEGFR inhibitor
• CAS No. 857876-30-3
• Calculated MW 569.44
• Formulation C22H23N5O2H3PO4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:OP(O)(O)=O.OP(O)(O)=O.CC1(C)CNC2=C1C=CC(NC(=O)C1=C(NCC3=CC=NC=C3)N=CC=C1)=C2
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:Kit; VEGFR1; VEGFR2; VEGFR2/Flk1; VEGFR3
  Boling pt:
  Melting pt:
  Solubility:Water: 19 mg/mL warmed (33.36 mM); DMSO: 100 mg/mL warmed (175.61 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Polverino A, et al. Y Res, 2006, 66(17), 8715-8721.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting