• Product NameSB590885
• Brief DescriptionInhibitors
• Purification96.61%
• Biological ActivitySB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM in a cell-free assay, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.
• Target NameRaf inhibitor
• CAS No. 405554-55-4
• Calculated MW 453.54
• Formulation C27H27N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN(C)CCOC1=CC=C(C=C1)C2=N/C(=C/3\C=CC4=C(CCC4=C3)N=O)/C(=C5C=CNC=C5)N2
  Pathways:MAPK
  Receptor:B-Raf
  Boling pt:
  Melting pt:
  Solubility:DMSO: 5 mg/mL (11.02 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. King AJ, et al. Y Res, 2006, 66(23), 11100-11105.2. Takle AK, et al. Bioorg Med Chem Lett, 2006, 16(2), 378-381.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting