• Product NameBMS-833923
• Brief DescriptionInhibitors
• Purification99.47%
• Biological ActivityBMS-833923 is an orally bioavailable Smoothened antagonist. Phase 2.
• Target NameHedgehog/Smoothened antagonist
• CAS No. 1059734-66-5
• Calculated MW 473.57
• Formulation C30H27N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CNCC1=CC(NC(=O)C2=CC=C(NC3=NC4=CC=CC=C4C(=N3)C3=CC=CC=C3)C=C2)=C(C)C=C1
  Pathways:GPCR/G Protein; Stem Cells
  Receptor:Smoothened
  Boling pt:
  Melting pt:
  Solubility:DMSO: 95 mg/mL (200.6 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tang JY, et al. Semin Cutan Med Surg. 2011, 30(4 Suppl), S14-18.2. Zaidi AH, et al. Y Invest. 2013, 31(7), 480-489.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting