• Product NameIcotinib Hydrochloride
• Brief DescriptionInhibitors
• Purification99.73%
• Biological ActivityIcotinib hydrochloride(BPI-2009H) is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an IC(50) of 5 nM, including it's mutants of EGFR(L858R), EGFR(L861Q), EGFR(T790M) and EGFR(T790M, L858R).
• Target NameEGFR inhibitor
• CAS No. 1204313-51-8
• Calculated MW 427.88
• Formulation C22H22ClN3O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:Cl.C#CC1=CC(NC2=NC=NC3=CC4=C(OCCOCCOCCO4)C=C23)=CC=C1
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR; EGFR mutants
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tan F, et al. Lung Y. 2012 May;76(2):177-82.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting